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Package carriers, such as DHL, FedEx, UPS, etc. usually carry letters and other small cargo weighing below 150 pounds using air, Truck, and rail to carry time-sensitive smaller packages. Companies use air cargo carriers for larger cargo and package carriers for more time-sensitive smaller cargo. A carrier takes investment decisions regarding their equipment; Shipper in contrast uses transportation to minimize total cost, while providing an appropriate level of responsiveness to the customers. The Key issues air carriers usually face include identifying the location and a number of hubs, assigning planes to routes, and maintaining a schedule of planes and crews, also available at different prices. The effectiveness of any mode of transportation is affected by the carrier as well as infrastructure and transportation policies, e.g., an airline’s goal is to maximize the daily flying time of a plane and generated revenue per trip. Supply Chains using modes of transportation, such as air, package carriers, trucking, rail, water, pipelines, intermodal, etc. The cargo moves from the factory premises to the port in a truck or multi-modal movement of truck and container on the rail. The shipper requires the movement of products from one point to another in a Supply Chain and Carrier is the party who moves the cargo. AI algorithms can optimize routes for each autonomous vehicle in real-time, based on traffic data, road conditions, and other factors. AI algorithms can mine historical and real-time traffic data to create predictive models to anticipate traffic congestion and accidents. AI will manage the optimum distance between vehicles, maintain constant communication between vehicles, and plan the formation of vehicle clusters to ensure consistent traffic flow and avoid bottlenecks. Air carriers usually carry below 500 pounds, high-value, and lightweight products.